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Registro completo
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Biblioteca (s) : |
INIA La Estanzuela. |
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Fecha : |
02/03/2017 |
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Actualizado : |
07/03/2017 |
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Autor : |
GARCIA, J.P; GIANNITTI, F.; FINNIE, J.W.; MANAVIS, J. .; BEINGESSER, J.; ADAMS ,V.; ROOD, J.I.; UZAL, F.A. |
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Afiliación : |
FEDERICO GIANNITTI, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay. |
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Título : |
Comparative Neuropathology of Ovine Enterotoxemia Produced by Clostridium perfringens Type D Wild-Type Strain CN1020 and Its Genetically Modified Derivatives. |
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Fecha de publicación : |
2015 |
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Fuente / Imprenta : |
Veterinary Pathology, 2015, v.52.n.6. p.1250-1253, 2015. |
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Idioma : |
Inglés |
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Contenido : |
Abstract
Clostridium perfringens type D causes enterotoxemia in sheep and goats. The disease is mediated by epsilon toxin (ETX), which affects the cerebrovascular endothelium, increasing vascular permeability and leading to cerebral edema. In the present study, we compared the distribution and severity of the cerebrovascular changes induced in lambs by C. perfringens type D strain CN1020, its isogenic etx null mutant, and the ETX-producing complemented mutant. We also applied histochemical and immunohistochemical markers to further characterize the brain lesions induced by ETX. Both ETX-producing strains induced extensive cerebrovascular damage that did not differ significantly between each other in nature, neuroanatomic distribution, or severity. By contrast, lambs inoculated with the etx mutant or sterile, nontoxic culture medium did not develop detectable brain lesions, confirming that the neuropathologic effects observed in these infections are dependent on ETX production. Lambs treated with the wild-type and complemented strains showed perivascular and mural vascular edema, as well as serum albumin extravasation, particularly severe in the cerebral white matter, midbrain, medulla oblongata, and cerebellum. Brains of animals inoculated with the ETX-producing strains showed decreased expression of glial fibrillary acidic protein and increased expression of aquaporin-4 in the end-feet processes of the astrocytes around blood vessels. Early axonal injury was demonstrated with anti?amyloid precursor protein immunohistochemistry. Perivascular accumulation of macrophages/microglia with intracytoplasmic albumin globules was also observed in these animals. This study demonstrates that ETX is responsible for the major cerebrovascular changes in C. perfringens type D?induced disease. MenosAbstract
Clostridium perfringens type D causes enterotoxemia in sheep and goats. The disease is mediated by epsilon toxin (ETX), which affects the cerebrovascular endothelium, increasing vascular permeability and leading to cerebral edema. In the present study, we compared the distribution and severity of the cerebrovascular changes induced in lambs by C. perfringens type D strain CN1020, its isogenic etx null mutant, and the ETX-producing complemented mutant. We also applied histochemical and immunohistochemical markers to further characterize the brain lesions induced by ETX. Both ETX-producing strains induced extensive cerebrovascular damage that did not differ significantly between each other in nature, neuroanatomic distribution, or severity. By contrast, lambs inoculated with the etx mutant or sterile, nontoxic culture medium did not develop detectable brain lesions, confirming that the neuropathologic effects observed in these infections are dependent on ETX production. Lambs treated with the wild-type and complemented strains showed perivascular and mural vascular edema, as well as serum albumin extravasation, particularly severe in the cerebral white matter, midbrain, medulla oblongata, and cerebellum. Brains of animals inoculated with the ETX-producing strains showed decreased expression of glial fibrillary acidic protein and increased expression of aquaporin-4 in the end-feet processes of the astrocytes around blood vessels. Early axonal injury was demonstrated wi... Presentar Todo |
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Thesagro : |
ENFERMEDADES DE LOS ANIMALES. |
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Asunto categoría : |
-- |
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Marc : |
LEADER 02512naa a2200217 a 4500
001 1056750
005 2017-03-07
008 2015 bl uuuu u00u1 u #d
100 1 $aGARCIA, J.P
245 $aComparative Neuropathology of Ovine Enterotoxemia Produced by Clostridium perfringens Type D Wild-Type Strain CN1020 and Its Genetically Modified Derivatives.$h[electronic resource]
260 $c2015
520 $aAbstract Clostridium perfringens type D causes enterotoxemia in sheep and goats. The disease is mediated by epsilon toxin (ETX), which affects the cerebrovascular endothelium, increasing vascular permeability and leading to cerebral edema. In the present study, we compared the distribution and severity of the cerebrovascular changes induced in lambs by C. perfringens type D strain CN1020, its isogenic etx null mutant, and the ETX-producing complemented mutant. We also applied histochemical and immunohistochemical markers to further characterize the brain lesions induced by ETX. Both ETX-producing strains induced extensive cerebrovascular damage that did not differ significantly between each other in nature, neuroanatomic distribution, or severity. By contrast, lambs inoculated with the etx mutant or sterile, nontoxic culture medium did not develop detectable brain lesions, confirming that the neuropathologic effects observed in these infections are dependent on ETX production. Lambs treated with the wild-type and complemented strains showed perivascular and mural vascular edema, as well as serum albumin extravasation, particularly severe in the cerebral white matter, midbrain, medulla oblongata, and cerebellum. Brains of animals inoculated with the ETX-producing strains showed decreased expression of glial fibrillary acidic protein and increased expression of aquaporin-4 in the end-feet processes of the astrocytes around blood vessels. Early axonal injury was demonstrated with anti?amyloid precursor protein immunohistochemistry. Perivascular accumulation of macrophages/microglia with intracytoplasmic albumin globules was also observed in these animals. This study demonstrates that ETX is responsible for the major cerebrovascular changes in C. perfringens type D?induced disease.
650 $aENFERMEDADES DE LOS ANIMALES
700 1 $aGIANNITTI, F.
700 1 $aFINNIE, J.W.
700 1 $aMANAVIS, J. .
700 1 $aBEINGESSER, J.
700 1 $aADAMS ,V.
700 1 $aROOD, J.I.
700 1 $aUZAL, F.A.
773 $tVeterinary Pathology, 2015$gv.52.n.6. p.1250-1253, 2015.
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Registro original : |
INIA La Estanzuela (LE) |
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Registro completo
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Biblioteca (s) : |
INIA Tacuarembó; INIA Treinta y Tres. |
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Fecha actual : |
21/02/2014 |
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Actualizado : |
11/06/2020 |
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Tipo de producción científica : |
Actividades de Difusión |
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Autor : |
INIA TREINTA Y TRES.; PROGRAMA NACIONAL PRODUCCIÓN DE CARNE Y LANA.; PROGRAMA NACIONAL PASTURAS Y FORRAJES.; AYALA, W.; BANCHERO, G.; BERMÚDEZ, R.; MONTOSSI, F.; OLIVIERI, V.; QUINTANS, G.; ROVIRA, P.J.; SARAVIA, H.; GARI, C.; TERRA, J.A.; VIÑOLES, C. |
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Afiliación : |
PROGRAMA NACIONAL DE INVESTIGACIÓN PRODUCCIÓN DE CARNE Y LANA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; PROGRAMA NACIONAL DE INVESTIGACIÓN PASTURAS Y FORRAJES, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; WALTER FELIZARDO AYALA SILVERA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; GEORGGET ELIZABETH BANCHERO HUNZIKER, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; RAÚL ENRIQUE BERMÚDEZ COQUARD, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; FABIO MARCELO MONTOSSI PORCHILE, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; VIRGINIA OLIVIERI, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; GRACIELA QUINTANS ILARIA, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; PABLO JUAN ROVIRA SANZ, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; HORACIO SARAVIA DIAZ, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; CAROLINA GARI, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; JOSÉ ALFREDO TERRA FERNÁNDEZ, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; CAROLINA VIÑOLES GIL, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay. |
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Título : |
Unidad Experimental Palo a Pique: día de campo. 2001. |
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Fecha de publicación : |
2001 |
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Fuente / Imprenta : |
Treinta y Tres (Uruguay): INIA, 2001. |
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Páginas : |
28 p. |
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Serie : |
(INIA Serie Actividades de Difusión; 259) |
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Idioma : |
Español |
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Contenido : |
Contiene:
Manejo agronómico de Trifolium alexandrinum cv. Calipso.
Producción de corderos pesados sobre Lotus Maku y Lotus el Rincón.
Producción intensiva de carne en sistemas de siembra directa.
Resultados de la inseminación artificial 2000.
Manejo de vaquillonas y terneras para el entore.
Manejo de vacas de primera cría.
Manejo de la majada de cría - 2001.
Mortalidad neonatal y crecimiento de corderos en relación con la producción de calostro en ovejas Corriedale.
Mortalidad neonatal y crecimiento de corderos asociado al comportamiento maternal en ovejas Corriedale. |
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Thesagro : |
GANADERIA; PRODUCCION ANIMAL; URUGUAY. |
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Asunto categoría : |
L01 Ganadería |
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URL : |
http://www.ainfo.inia.uy/digital/bitstream/item/10532/1/dc-UEPP2001.pdf
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Marc : |
LEADER 01477nam a2200325 a 4500
001 1061121
005 2020-06-11
008 2001 bl uuuu u00u1 u #d
100 1 $aINIA TREINTA Y TRES.
245 $aUnidad Experimental Palo a Pique$bdía de campo. 2001.
260 $aTreinta y Tres (Uruguay): INIA$c2001
300 $a28 p.
490 $a(INIA Serie Actividades de Difusión; 259)
520 $aContiene: Manejo agronómico de Trifolium alexandrinum cv. Calipso. Producción de corderos pesados sobre Lotus Maku y Lotus el Rincón. Producción intensiva de carne en sistemas de siembra directa. Resultados de la inseminación artificial 2000. Manejo de vaquillonas y terneras para el entore. Manejo de vacas de primera cría. Manejo de la majada de cría - 2001. Mortalidad neonatal y crecimiento de corderos en relación con la producción de calostro en ovejas Corriedale. Mortalidad neonatal y crecimiento de corderos asociado al comportamiento maternal en ovejas Corriedale.
650 $aGANADERIA
650 $aPRODUCCION ANIMAL
650 $aURUGUAY
700 1 $aPROGRAMA NACIONAL PRODUCCIÓN DE CARNE Y LANA.
700 1 $aPROGRAMA NACIONAL PASTURAS Y FORRAJES.
700 1 $aAYALA, W.
700 1 $aBANCHERO, G.
700 1 $aBERMÚDEZ, R.
700 1 $aMONTOSSI, F.
700 1 $aOLIVIERI, V.
700 1 $aQUINTANS, G.
700 1 $aROVIRA, P.J.
700 1 $aSARAVIA, H.
700 1 $aGARI, C.
700 1 $aTERRA, J.A.
700 1 $aVIÑOLES, C.
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